Thinakaran Lab - Cell Biology of Alzheimer's Disease

As a graduate student, I worked on the therapeutic roles of potential drug candidates on Alzheimer’s disease (AD). The treatment of AD has been a big challenge and there is currently no safe and effective drug to prevent or cure the disease. In this sense, the ongoing research focuses on therapies with combined actions which target many aspects of AD neuropathology. Specifically, I analyzed the effects of very potent cholinesterase inhibitors on amyloid and tau pathologies by using in vitro and in vivo models of AD, with the hope of possible use of them as a disease-modifying drug for AD treatment. In the Thinakaran lab, I work on the characterization of the mechanisms and pathways associated with recently identified AD genetic risk factors.